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KMID : 1200020110350040317
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Diabetes & Metabolism Journal
2011 Volume.35 No. 4 p.317 ~ p.326
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Polymeric Gene Delivery for Diabetic Treatment
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Kim Sung-Wan
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Abstract
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Several polymers were used to delivery genes to diabetic animals. Polyaminobutyl glycolic acid was utilized to deliver IL-10 plasmid DNA to prevent autoimmune insulitis of non-obese diabetic (NOD) mouse. Polyethylene glycol grafted polylysine was combined with antisense glutamic acid decarboxylase (GAD) MRNA to represent GAD autoantigene expression. GLP1 and TSTA (SP-EX4) were delivered by bioreducible polymer to stop diabetic progression. Fas siRNA delivery was carried out to treat diabetic NOD mice animal.
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KEYWORD
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Il-10 plasmid DNA, GAD MRNA, SP-Ex4, FasSiRNA
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FullTexts / Linksout information
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Listed journal information
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